At 12 years of age he was left orphaned. Lucian distributed his possessions to the poor, and went to the city of Edessa to the confessor Macarius, under the guidance of whom he diligently read Holy Scripture and learned the ascetic life. For his pious and zealous spreading of Christianity among the Jews and pagans, Lucian was made a presbyter.
In Antioch St Lucian opened a school where many students gathered. He taught them how to understand the Holy Scriptures, and how to live a virtuous life. St Lucian occupied himself with teaching, and he corrected the Greek text of the Septuagint, which had been corrupted in many places by copyists and by heretics who deliberately distorted it in order to support their false teachings. The entire Greek text of the Bible which he corrected was hidden in a wall at the time of his confession of Christ, and it was found during the lifetime of St Constantine the Great.
During the persecution of Diocletian, St Lucian was arrested and was sent to prison in Nicomedia, where for nine years he encouraged other Christians with him to remain steadfast in their confession of Christ, urging them not to fear tortures or death.
St Lucian died in prison from many terrible tortures and hunger. Before his death, he wished to partake of the Holy Mysteries of Christ on the Feast of Theophany. Certain Christians who visited him brought bread and wine for the Eucharist. The hieromartyr, bound by chains and lying on a bed of sharp potsherds, was compelled to offer the Bloodless Sacrifice upon his chest, and all the Christians there in prison received Communion. The next day the emperor sent people to see if 
the saint was still alive. St Lucian said three times, “I am a Christian,” then surrendered his soul to God. The body of the holy martyr was thrown into the sea, but after thirty days dolphins brought it to shore. Believers reverently buried the body of the much-suffering St Lucian.